Abstract
A prospective randomized placebo-controlled study with 300 patients was performed in order to evaluate the potentially beneficial effects of long-term treatment with oral anticoagulants (Fenprocoumon, Marcoumar) in patients with chronic peripheral arterial obstructive disease. Both conservatively and surgically treated patients were included. The difference in progression of peripheral vascular disease, cardiovascular disease and cerebrovascular disease is statistically highly significant (p<0.0001, log-rank test) in favour of oral anticoagulants. Bleeding complications were relatively infrequent in both groups. Conclusion: the long-term use of oral anticoagulants is recommended for the treatment of patients with chronic peripheral atherosclerotic obstructive disease, both after surgical vascular reconstructions and as an adjunct to conservative treatment regimens.
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