Duration of Left Ventricular Assist Device Support Does Not Impact Survival After US Heart Transplantation

Abstract

The aim of this study was to determine whether the duration of left ventricular device support (LVAD) influenced outcomes after orthotopic heart transplantation in a modern, bridge to transplant national cohort. The United Network for Organ Sharing database, which has recently made pretransplant LVAD duration available, was queried for all adult bridge to transplant patients between January 2011 and December 2012. Three LVAD duration cohorts were generated, as follows: short (less than 90 days), intermediate (90 to 365days), and prolonged (more than 365 days). Recipient,donor, and transplant-specific characteristics were compared among the duration cohorts. Unadjusted short-term and long-term survivals were estimated with the Kaplan-Meier method. Risk-adjusted models were also constructed to determine the independent impact of device duration on mortality. Of the 1,332 patients who met criteria for inclusion, 9.8% (n= 130), 54.7% (n= 729), and 35.5% (n= 473) were classified as short, intermediate, and prolonged, respectively. Although the performance statusacross eachcohort was similar at listing (p= 0.38), more patients in the intermediate and prolonged cohortswere considered functionally independent beforeorthotopic heart transplantation (32% and 37%, respectively, versus 18%; p < 0.001). Additionally, despite worse baseline renal function in the intermediate and prolonged cohorts relative to the short cohort (glomerular filtration rate, 57 and 57 versus 69, p < 0.001), there was nodifference in the incidence of new onset posttransplant renal failure (7% versus 10%, 9%, p= 0.41). There was also no difference in 30-day survival (98%, 96%, 95%, p= 0.51), 6-month survival (93%, 92%, 92%, p= 0.93), or1-year survival (91%, 89%, 89%, p= 0.78) across the cohorts. After risk adjustment, duration did not independently predict mortality at any timepoint. In the largest, non-industry sponsored study of a modern bridge to transplant cohort, we demonstrated that duration of LVAD support before orthotopic heart transplantation does not influence posttransplant morbidity or mortality. In subanalysis, support for 90 days or more is associated with improvements in pretransplant functional performance.