Abstract
Introduction. The ductus venosus is a intrahepatic venous connection between the left portal vein and inferior vena cava in the fetus. Regarding agenesis of the ductus venosus (DVA) real incidence in not known. Material and methods. In high-risk population its prevalence is reported as up to 1 in 2500 cases. Approximatively 20% of DVA may be asymptomatic. Cardiac, extracardiac and chromosomal anomalies may be associated. We conducted a review analyzing a total of 7 studies and a total of 151 cases of pregnancies with DVA. Results. 19.2% cases were isolated incidental findings with no other anomalies associated. Overall adverse outcome was identified in 74 cases, mostly due to chromosomal anomalies, multiple malformations, and cardiac anomalies. For 40 of these cases termination of pregnancy was recommended. Although 104 of pregnancies reached postpartum life, death occurred in 19 cases after birth. Conclusions. In cases with isolated DVA discovery, the prognosis is favorable, thereby counseling should be reassuring. However, a careful assessment of the umbilical vein connections and a careful second trimester screening for cardiac and extracardiac anomalies should be performed.
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