Abstract
Oxidative stress plays an important role in acute and chronic inflammatory diseases. However, the clinical treatment options for oxidative stress-related diseases are limited. Nanozyme with excellent reactive oxygen species (ROS) catalytic capacity are promising for preventing ROS-related inflammation. Herein, we designed CeO2:Yb7Tm0.5 with a butterfly-like structure of upconversion nanoparticles (UCNPs) with enzyme-mimicking ability. The CeO2:Yb7Tm0.5 UCNPs have catalase and glutathione peroxidase-mimicking enzyme properties, which can treat acute lung injury (ALI). The CeO2:Yb7Tm0.5 UCNPs turn blue, green, white, and red under upconversion luminescence with increasing temperature from 298 K to 358 K. Here, the changing of color are examined over the temperature range of in 298 K-373 K in 10 K increments. Maximum absolute and relative sensitivities (Sa and Sr) of 2.3 % K−1 and 2.7 % K−1 are obtained at 298 K and 373 K, respectively. The butterfly-like structure of CeO2:Yb/Tm is promising for biological application, such as accurate cell temperature detection, bio-catalysis diagnostics and ALI treatment.
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