Abstract
Around 25–33% of patients with acute decompensated heart failure develop worsening kidney function, a condition referred to as acute cardiorenal syndrome (type 1). Diuretics are commonly used to treat persistent congestion in these patients, but these drugs might worsen kidney function. An alternative therapeutic approach is venovenous ultrafiltration, which can improve control over the rate and volume of fluid removal, increase net loss of sodium, and reduce neurohormonal activation. To address the lack of data on the use of ultrafiltration in patients with acute decompensated heart failure, investigators designed CARRESS-HF, the results of which were presented at the AHA 2012 Scientific Sessions and published in the New England Journal of Medicine.
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