Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio

Abstract

Acute changes in spontaneous motor activity, the EEG and photically induced epileptic responses have been observed in baboons ( Papio papio) following the i.v. injection of drugs acting on dopaminergic transmission. Apomorphine hydrochloride, 0.5–1.0 mg/kg, produced a phase of acute excitement with accentuated vigilance and abnormal buccal motor activity lasting 30–40 min; during this phase myoclonic responses to intermittent photic stimulation were absent. After piribedil (ET 495, 1,2″-pyrimidyl-4-piperonylpiperazine), 2–10 mg/kg, acute excitement was not seen. Intermittent δ activity was prominent in the EEG for 1–3 hr, and was associated with a slight reduction in photically induced epileptic responses. Haloperidol 0.6–1.2 mg/kg, produced a long-lasting reduction in spontaneous motor activity with an increased incidence of spontaneous EEG spikes and waves and a great enhancement of paroxysmal EEG activity during photic stimulation. Pimozide, 0.5–2.5 mg/kg, normally produced mild sedation and some EEG slowing. 2 animals responded idiosyncratically to both haloperidol and pimozide, displaying intermittent dystonic episodes with bucco-facial dyskinesia. These findings suggest that activation of dopaminergic receptors can lead to a reduction in myoclonic responses to photic stimulation.