Abstract
Idiosyncratic drug-induced liver injury (DILI) can present with autoimmune features, including positive autoantibodies, hypergammaglobulinemia, and lymphoplasmocytic inflammation on liver biopsy. Differentiating between DILI and idiopathic autoimmune hepatitis (iAIH) can be challenging in part because it is often difficult to establish DILI causality. Drug discontinuation is the main treatment of DILI with autoimmune features, though immunosuppression is indicated in certain circumstances, such as DILI with immunoallergic features. This chapter will address how to differentiate between DILI and iAIH and discuss some of the drugs that are most commonly associated with an autoimmune phenotype.
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