Abstract
An in vitro model to simulate some factors involved in the absorption process is described. It consists of a tube containing two aqueous phases separated by an immiscible phase. A rocking apparatus agitates the fluids while causing the liquid interfaces to expand and contract. Rates of drug transfer and equilibrium drug distribution were determined under conditions where one aqueous phase was maintained at pH 7.4 and the other buffered at various pH values. Salicylic acid, barbital, antipyrine, aminopyrine, and tetracycline were studied in this manner. The initial drug transfer simulated a first-order rate process. Results of the equilibrium studies are in general agreement with predictions of the pH-partition theory. Tetracycline did not undergo transfer from one aqueous phase to the other at any pH condition of the study.
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