Abstract
Summary The in vitro activity of the microsomal enzymes (hydroxylation and N-demethylation), the concentration of the cytochrome P-450 and the hexobarbital sleeping time of hypertensive rats did not differ significantly from those of normotensive rats. On the basis of these findings it is improbable that the increased blood pressure of hypertensive rats results from the changed metabolism of endogenous blood pressure regulating agents disposed by microsomal enzymes.
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