Abstract
Hepatotoxicity in HIV is associated with anti-retroviral regimens and hepatitis B and C virus coinfection. Altered liver enzymes activities in HIV mono infected patients yet to commence and those on HAART for at least six months were studied. 45 HIV seropositive patients on HAART for at least six months attending LAUTECH Teaching Hospital, Osogbo, Nigeria, 40 newly diagnosed HIV seropositive patients yet to commence HAART (naive) and 40 HIV- negative subjects (control) were recruited. 5 ml venous blood was drawn from each subject. Serum liver function tests were estimated by spectrophotometry. Hepatitis B surface antigen and antibody to hepatitis C virus were determined using ELISA. Data were analyzed statistically and p 2-fold increase in alkaline phosphatase and AST in HIV-HAART than in controls . Conjugated bilirubin was slightly lower in control subjects than in HIV-HAART and naive groups. All subjects were negative for HBsAg and anti-HCV. Even in the absence of HAART, mild hepatotoxicity is seen in HIV patients.
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