Abstract
Spinal cord injury (SCI) and ankylosing spondylitis (AS) are common inflammatory diseases in spine surgery. However, it is a project where the relationship between the two diseases is ambiguous and the efficiency of drug discovery is limited. Therefore, the study aimed to investigate new drug therapies for SCI and AS. First, text mining was used to obtain the interacting genes related to SCI and AS, and then, the functional analysis was conducted. Protein–protein interaction (PPI) networks were constructed by STRING online and Cytoscape software to identify hub genes. Last, hub genes and potential drugs were performed after undergoing drug–gene interaction analysis, and MicroRNA and transcription factors regulatory networks were also analyzed. Two hundred five genes common to “SCI” and “AS” identified by text mining were enriched in inflammatory responses. PPI network analysis showed that 30 genes constructed two significant modules. Ultimately, nine (SST, VWF, IL1B, IL6, CXCR4, VEGFA, SERPINE1, FN1, and PROS1) out of 30 genes could be targetable by a total of 13 drugs. In conclusion, the novel core genes contribute to a novel insight for latent functional mechanisms and present potential prognostic indicators and therapeutic targets in SCI and AS.
Highlights
Spinal cord injury (SCI) is a serious complication of traumatic diseases such as spinal fracture or dislocation, burdening families, economics, and society (GBD 2017 US Neurological Disorders Collaborators et al, 2021)
The incidence of SCI appears to be higher in patients with ankylosing spondylitis (AS) than in the general population, which, is directly related to the increasing incidence of vertebral column fracture in patients with AS (Jacobs and Fehlings, 2008)
This study aimed to mine the correlations between the SCI and AS, further obtaining new drugs to control the progression of the two, including text mining, genetic functional analysis, protein–protein interaction (PPI) analysis, drug–gene interaction, and related regulatory molecular analysis
Summary
Spinal cord injury (SCI) is a serious complication of traumatic diseases such as spinal fracture or dislocation, burdening families, economics, and society (GBD 2017 US Neurological Disorders Collaborators et al, 2021). The relationship between the two diseases is unclear and the efficiency of drug discovery is limited. If patients with AS happen to have SCI, the question whether AS aggregates the injury degree of the spinal cord needs to be answered. Mining the underlying pathomechanism is a necessary way to further understand the relationship between the two diseases and discover potential therapies for destroying their interaction. Under the pathologic mechanism of the disease, combined with an unstable spine, the AS population is predisposed to highly distracting injuries and spinal epidural hematoma
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