Abstract
Infection by human Coronaviruses (CoVs) such as HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1generally results in moderate to severe respiratory and intestinal infections in humans. The deadly human CoVs emerging in the last two decades however became the cause of great global concern. The severe acute respiratory syndrome (SARS) SARS-CoV, Middle East respiratory syndrome (MERS) (MERS-CoV) and the current SARS-CoV-2 that causes COVID-19 are related respiratory infections with high degree of mortality.
Highlights
Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals.[1]
The Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses has formally designated the virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[6]
Labyrinthopeptins A1 and A2, were found to inhibit the proliferation of many enveloped viruses including dengue virus, Zika virus, West Nile virus, hepatitis C virus, chikungunya virus, Kaposi’s sarcoma-associated herpes virus, cytomegalovirus, and herpes simplex virus with mechanism of action showing that it induced virolytic effect through binding to the viral membrane lipid phosphatidylethanolamine (PE).[210]
Summary
Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals.[1].
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