Abstract
It is now more than fifty years since Burg made a signal advance in the study of renal physiology by reporting a method of isolating and perfusing tubules from selected regions of the kidney. Prior to this, knowledge of renal tubular function had been derived either from micropuncture experiments, limited to the superficial regions of the kidney, from kidney slices, which were subject to injury and represented an aggregate of tubular function, or from renal cells in tissue culture
Highlights
Knepper and colleagues have applied these techniques to a well-studied phenomenon, the effect of lithium on the renal tubules [11]
Use of the anti-inflammatory agent dexamethasone, which blocks the inflammatory response to an increase in NF-κB, resulted in an increase in AQP2 abundance in Li-treated rats [11]
It would have been of interest, to know what if any impact dexamethasone had on the other up-regulated pathways
Summary
Knepper and colleagues have applied these techniques to a well-studied phenomenon, the effect of lithium on the renal tubules [11]. A further study of the time course of activation of the early response genes revealed a rapid rise, over 24 hours, in abundance of transcripts of known immediate early genes, followed by a decrease, whereas gene groups associated with a proliferative response showed little activity at 24 hours but a progressive increase thereafter. In contrast there was a maintained decrease in transcripts encoding for Transporters and Channels, consistent with the observed physiological responses [11].
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