Abstract
The subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established therapy in advanced Parkinson's disease (PD) for motor fluctuations and symptoms including akinesia, rigidity, and tremor. However, its efficiency in axial symptoms, particularly freezing of gait (FOG), is controversial. In this report, we present a 73-year-old female patient with PD who had undergone STN-DBS therapy 7 years before due to advanced PD. The patient applied to our movement disorder polyclinic due to gait difficulty mainly characterized by FOG episodes. The adjustments of the stimulation parameters revealed a dramatic improvement in FOG that is illustrated by follow-up video images. The efficiency of DBS therapy in FOG, a problem of a transient network malfunction, even in the chronic phase of the therapy, may provide crucial contributions to the unknown aspects of DBS therapy, and also the pathophysiology of FOG. We think that the presentation of this specific case is illustrative and provides substantial remarks.
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