Abstract

Here, we report the draft genome sequence of a methicillin-resistant Staphylococcus aureus (MRSA) strain with high-level mupirocin resistance (SA_ST125_MupR), isolated from a patient with recurrent bacteremia. This strain belonged to sequence type ST125, which was responsible for more than 50% of the health care-associated infections caused by MRSA in Spain.

Highlights

  • We report the draft genome sequence of a methicillin-resistant Staphylococcus aureus (MRSA) strain with high-level mupirocin resistance (SA_ST125_MupR), isolated from a patient with recurrent bacteremia

  • With increasing pressure to prevent MRSA infection, it is possible that there will be increased use of mupirocin for nasal decolonization of MRSA (3), which will be reflected in increased rates of resistance (4)

  • We detected 8.8% High-level mupirocin resistance (Hi-MupR) among MRSA isolates, and most of this resistance was focused on the ST125 clone (5)

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Summary

Introduction

We report the draft genome sequence of a methicillin-resistant Staphylococcus aureus (MRSA) strain with high-level mupirocin resistance (SA_ST125_MupR), isolated from a patient with recurrent bacteremia. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most frequently identified antimicrobial drug-resistant pathogens worldwide. It has been demonstrated that some lineages are ecologically highly successful and that most isolates belong to pandemic clones (1).

Results
Conclusion

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