Abstract
Lactobacillus salivarius is part of the vertebrate indigenous microbiota of the gastrointestinal tract, oral cavity, and milk. The properties associated with some L. salivarius strains have led to their use as probiotics. Here we describe the draft genome of the pig isolate L. salivarius cp400, providing insights into host-niche specialization.
Highlights
The Gram-positive bacterium Lactobacillus salivarius is an important member of the pig microbiota [1] and a promising probiotic candidate frequently isolated from human, porcine, and avian gastrointestinal tracts, many of which are producers of unmodified bacteriocins [2]
To gain novel insights into the molecular basis underlying L. salivarius adaptation to the intestinal ecological niche, we have determined the genome sequence of the pig isolate L. salivarius cp400, isolated from preweaned piglet feces (Stefan Roos, unpublished data)
Analysis of the bacteriocin gene cluster revealed high homology to the Abp118 gene cluster, encoding a class IIb two-peptide bacteriocin composed of Abp118alpha, exhibiting antimicrobial activity, and Abp118beta, which enhanced the antimicrobial activity in L. salivarius UCC118 [12]
Summary
The Gram-positive bacterium Lactobacillus salivarius is an important member of the pig microbiota [1] and a promising probiotic candidate frequently isolated from human, porcine, and avian gastrointestinal tracts, many of which are producers of unmodified bacteriocins [2]. Genomic DNA was purified using a modified method from Oh and colleagues [4] and used to generate over 4.65 Gbp of sequence on the Illumina HiSeq2000 platform.
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