Abstract
The synthesis of water-soluble quantum dots (QDs) has recently received extensive attention due to noninvasive detection of biological information in living subjects. In this paper, high-quality water-soluble (cadmium-free) quaternary AgZnInS QDs have been successfully synthesized using a green synthetic route. The as-prepared QDs exhibit tunable photoluminescence (PL) emission between 521 and 658 nm. Secondly, multidrug resistance (MDR) is a major impediment to the effective cancer chemotherapy. DOX, a widely used antitumor drug was modified on the surface of the QDs in this study. It, therefore, significantly enhanced the cytotoxicity of DOX to MDR cancer cells as the QDs could bring the DOX to nucleus.
Highlights
Medical imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound imaging, and optical imaging, play key roles in disease diagnosis.[1,2] Each imaging technique can bring unique information to molecular medicine
In our aqueous synthesis of ZAIS quantum dots (QDs), quaternary ZnAgInS (ZAIS) QDs were initially produced by the reaction of silver nitrate, zinc acetate, indium acetate with polycarboxylate (i.e., PAA) and thiolfunctionalized (i.e., MAA) ligands in the presence of sodium sulde at 50C
We focus on the e®ect of the thiol-functionalized (i.e., MAA) ligands on the quaternary ZnAgInS (ZAIS) QDs °uorescence properties
Summary
Medical imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound imaging, and optical imaging, play key roles in disease diagnosis.[1,2] Each imaging technique (or modality) can bring unique information to molecular medicine. °uorescence, conveniently tunable size, and narrow size distribution, have been successfully prepared through an organometallic route or an aqueousbased approach Their e±cient emission mostly ranged from green to NIR region (500– 750 nm), i.e., relatively limited reports on the synthesis of QDs with violet–blue emission between 400 and 500 nm, especially in aqueous media. Several groups' reports have shown the cytotoxicity of QDs is due to the eventual release of toxic components into the cellular environment This represents a major obstacle to the clinical use of QDs and has motivated the development of new biocompatible QDs based on the use of I-II-III or I-III-VI2 materials with relatively low toxicity.[9,10] ZnAgInS QD is a I-II-III semiconductor QD, corresponding to a 600 nm emission wavelength, and does not contain highly toxic heavy metals. In this sense, realizing a su±ciently high intracellular level of cytotoxic chemicals using an optimized delivery system might represent a novel tactic in overcoming the MDR of cancer cells, while the intracellular accumulation of drug and the intracellular release of drug molecules from the carrier could be the most important barriers for nanoscale carriers in overcoming MDR
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