Abstract
Down Syndrome (DS) or trisomy 21 (T21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,. Average incidence of this syndrome is about 1:700 newborns. Numerous researchers noted thyroid disorders in people with Down Syndrome but, clinical symptoms of thyroid dysfunction are difficult to separate from DS phenotype. The aim of this study was to examine the thyroid function in the patients with DS. Our results confirmed higher frequency of thyroid dysfunction in DS patients. Higher values of TSH were found in 60,34% of the examined DS patients, which is significantly higher value comparing with the control group (p<0,01). Compensated hypothyroidism was established in 27,92% of the examined DS patients, and most of those (63,23%) were younger than 6 years. The conclusions emphasize the necessity of implementation of thyroid function screening program in persons with DS, and the need for adequate treatment of its dysfunction. Thus, the symptoms of the disease would be alleviated and better physical and mental fitness ensured.
Highlights
MENSUDA HASANHODŽIĆ ET AL.: DOWN SYNDROME AND THYROID GLAND ues of TSH are significantly higher in the DS sub-group with elevated serum levels of TSH (p
When comparing the age groups, we found no differences between values of T in the tested with DS and the control group, which is consistent with the results of other authors (, )
Our studies confirmed significantly higher frequency of thyroid dysfunction in people with DS comparing with the control group
Summary
MENSUDA HASANHODŽIĆ ET AL.: DOWN SYNDROME AND THYROID GLAND ues of TSH are significantly higher in the DS sub-group with elevated serum levels of TSH (p< , ) comparing to the values of the DS sub-group with normal level of TSH and the values of both control sub-groups. In both tested DS sub-groups rT /TSH ratio is significantly lower (p< , ) comparing to the both control sub-groups. TSH values higher than , mU/L, the number of tested with positive antibodies is times greater than among the tested with average TSH values within referent levels
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