Abstract
The two double-quantum filtered MRI pulse sequences, DQF and DQF-MT produce image contrast based on differences in the residual intramolecular dipolar interactions of water in the various types of tissue. Magnetization exchange between water and macromolecules gives image contrast in the DQF-MT method that distinguishes various components of tissues on the basis of differences in their macromolecular properties. In order to avoid the introduction of contrast due to differences in T2 of the various water populations (hundreds of microseconds), double-quantum filtering imaging of tendons and other tissues was combined with an ultrashort time to echo (UTE) acquisition. The above methods distinguish water populations and macromolecular properties in tendons, the annulus fibrosus, and muscles in the rat tail. The techniques were also used to monitor the healing of injured tendons in small animals. Implementation of DQF MRI on a human subject in a clinical scanner opens the way for important clinical applications. Keywords: double-quantum filtered NMR; DQF; DQF-MT; UTE; tendon; annulus fibrosus; collagen; residual dipolar interaction
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