Abstract
Photo-biocatalysis, the combination of photosensitization and biocatalysis, is an emerging solution for sunlight-based renewable energy. It is thus important to develop light antennas with both good light harvesting and efficient electron transfer. Herein, the intriguing electrical conductivity of dsDNA and its host effect (for nucleic acid dyes to harvest light) were explored simultaneously to develop a dsDNA-based light antenna for photo-biocatalysis. With SYBR Green I (SG) as the example of the nucleic acid dye, the proposed SG-dsDNA system was found to be capable for visible-light-driven reduced nicotinamide adenine dinucleotide (NADH) regeneration, and the turnover frequency of which (1.35 min−1) exceeded most of the existing photocatalytic systems. Since SG can only be hosted by dsDNA, meanwhile dsDNA can be formed through hybridization between single strand DNA and its complementary strand, the proposed system adds an extra control of the photocatalytic activity (DNA base pairing-based switch). When integrating the SG-dsDNA system with NADH-dependent horse liver alcohol dehydrogenase (HLADH), successful synthesis of 2-phenylpropanol (a crucial intermediates of profens manufacturing) was achieved.
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