Abstract
With the aim of developing humic preparations for medical use, we investigated two naturally occurring and three synthetic humic substances (HS) for their effects on inflammation, spontaneous contractile activity (SCA) of smooth muscles, and the reaction time of blood coagulation. The results indicate that low concentrations (1–10 μg/mL) of HS enhanced the SCA of smooth muscle strips from guinea pigs by stimulating alpha(2)-adrenoceptors and dopamine D2 receptors, intermediate HS concentrations (10–250 μg/mL) reduced the release of tumor necrosis factor-alpha (TNF-α), and high HS concentrations (250–1,000 μg/mL) acted as anticoagulants. A few humic samples were found to exhibit bimodal dose–response curves that will have to be further investigated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
