Abstract
A recently introduced brachytherapy system for partial breast irradiation, MammoSite, consists of a balloon applicator filled with contrast solution and a catheter for insertion of an I192r high‐dose‐rate (HDR) source. In using this system, the treatment dose is typically prescribed to be delivered 1 cm from the balloon's surface. Most treatment‐planning systems currently in use for brachytherapy procedures use water‐based dosimetry with no correction for heterogeneity. Therefore, these systems assume that full scatter exists regardless of the amount of tissue beyond the prescription line. This assumption might not be a reasonable one, especially when the tissue beyond the prescription line is thin. In such a case, the resulting limited scatter could cause an underdose to be delivered along the prescription line. We used Monte Carlo simulations to investigate how the thickness of the tissue between the surface of the balloon and the skin or lung affected the treatment dose delivery. Calculations were based on a spherical water phantom with a diameter of 30 cm and balloons with diameters of 4 cm, 5 cm, and 6 cm. The dose modification factor is defined as the ratio of the dose rate at the typical prescription distance of 1 cm from the balloon's surface with full scatter obtained using the water phantom to the dose rate with a finite tissue thickness (from 0 cm to 10 cm) beyond the prescription line. The dose modification factor was found to be dependent on the balloon diameter and was 1.098 for the 4‐cm balloon and 1.132 for the 6‐cm balloon with no tissue beyond the prescription distance at the breast–skin interface. The dose modification factor at the breast–lung interface was 1.067 for the 4‐cm balloon and 1.096 for the 6‐cm balloon. Even 5 cm of tissue beyond the prescription distance could not result in full scatter. Thus, we found that considering the effect of diminished scatter is important to accurate dosimetry. Not accounting for the dose modification factor may result in delivering a lower dose than is prescribed.PACS number: 87.53.Jw
Highlights
A new high-dose-rate (HDR) brachytherapy system, the MammoSite Radiation Therapy System (Proxima Therapeutics Inc., Alpharetta, GA), has been introduced recently to deliver partial breast irradiation after a lumpectomy for early-stage breast cancer.[1,2,3,4,5] The system is designed to treat the tissue immediately surrounding the lumpectomy cavity by inserting a multilumen balloon catheter into the cavity at the time of the surgery or shortly thereafter
The balloon, which is currently available in two sizes (4 cm to 5 cm and 5 cm to 6 cm), is inflated with a contrast solution
We believed that the resulting limited scatter could cause an underdose to be delivered along the prescription line
Summary
A new high-dose-rate (HDR) brachytherapy system, the MammoSite Radiation Therapy System (Proxima Therapeutics Inc., Alpharetta, GA), has been introduced recently to deliver partial breast irradiation after a lumpectomy for early-stage breast cancer.[1,2,3,4,5] The system is designed to treat the tissue immediately surrounding the lumpectomy cavity by inserting a multilumen balloon catheter into the cavity at the time of the surgery or shortly thereafter. The balloon, which is currently available in two sizes (4 cm to 5 cm and 5 cm to 6 cm), is inflated with a contrast solution. This causes the tissue to shape into an approximately spherical shell. A typical treatment prescription is 34 Gy delivered in fractions of 3.4 Gy twice per day for 5 days with a minimum of 6 h between fractions. The dose typically is prescribed to be delivered 1 cm from the balloon’s surface. A distance of 5 mm to 7 mm between the skin and the balloon’s surface is commonly used as a minimum for such treatments.[5]
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