Abstract
Healthy young volunteers received a purine-free formula diet for 18 days. Allopurinol (A) was given from day 11-18 in single oral doses of 125, 250, 375 and 500 mg/m2 body surface to 4, 8, 4 and 8 subjects, respectively. In a second study 4 of the 8 subjects on 250 and 500 mg/m2 took the same doses with the formula diet being supplemented by 4 g RNA/d. Maximum reduction of renal uric acid excretion was 55% and 70% during purine-free diet and RNA intake, respectively. On 250 and 500 mg/m2 reduction of endogenous renal uric acid was 36 and 46%, while exogenous uric acid was reduced by 74 and 86%, respectively in the 4 subjects. Renal uric acid clearance was increased by A during purine-free diet, but was not during RNA loading. In a different series of experiments A was given alone first followed by additional purine intake. On this regimen uric acid excretion did not increase during purine ingestion in most instances. This suggests previous inhibition by A or stimulation by oral purines of xanthine oxydase to be a factor in determining the influence of A on exogenous uric acid production.
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