Abstract
Fecal microbiota transplantation (FMT) has been recognized as a promising treatment for dysbiosis-related diseases. Since 2014, FMT has been utilized to treat ulcerative colitis (UC) in our clinical studies and has shown efficacy and safety. As donor screening (DS) is the primary step to ensure the safety of FMT, we report our experience with DS and present the screening results to improve the prospective DS criteria and provide references for future studies. The donor candidates were screened according to the DS criteria. The first DS criteria were proposed in June 2014 and revised substantially in May 2018. We further sorted the screening results and costs of laboratory tests. From June 2014 to April 2018, the DS eligibility rate was 50%. The total laboratory testing cost for each candidate was JPY 17,580/USD 160.21. From May 2018 to September 2021, the DS eligibility rate was 25.6%. The total laboratory testing cost for each candidate was JPY 40,740/USD 371.36. The reduction in donor eligibility rates due to more stringent criteria should be considered for cost and safety. Studies must consider the latest updates and make timely modifications in the DS criteria to ensure patient safety.
Highlights
Accepted: 16 February 2022Fecal microbiota transplantation (FMT), a therapeutic regimen for transplanting healthy donor feces to reprogram the recipient’s gut microbiota, has been proposed as a promising treatment for a wide range of dysbiosis-related diseases [1,2,3,4,5]
The pathogenesis of ulcerative colitis (UC) is not yet fully understood, previous reports have shown that dysbiosis caused by a decline in the diversity and abundance of intestinal microbiota in patients with UC
Feces donated by siblings provide a greater long-term remission rate than those obtained from a parent or an offspring [26]
Summary
Fecal microbiota transplantation (FMT), a therapeutic regimen for transplanting healthy donor feces to reprogram the recipient’s gut microbiota, has been proposed as a promising treatment for a wide range of dysbiosis-related diseases [1,2,3,4,5]. The pathogenesis of UC is not yet fully understood, previous reports have shown that dysbiosis caused by a decline in the diversity and abundance of intestinal microbiota in patients with UC is related to the development of the aberrant immunological response observed in IBD cases [12,13,14]. In a meta-analysis of four randomized controlled trials, the clinical remission rate of patients with UC who had undergone FMT was 42.1%, which was significantly higher than that of the control group, which was 22.6% [15]. Because of its efficacy, FMT has been studied extensively as a promising treatment for UC
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