Abstract
Neuroscience![Figure][1] CREDIT: © KUVAARIO/ALAMY Sleep deprivation has long been established as a helpful tool for the treatment of patients suffering from depression. However, how and why it works are still unknown. Functional magnetic resonance imaging (fMRI) studies have indicated that large-scale brain network connectivity, especially in the so-called default mode network, seems to be changed in depression. Bosch et al. investigated whether sleep deprivation could influence this brain connectivity. They discovered that sleep deprivation decreased functional connectivity between a brain area called the posterior cingulate cortex and the bilateral anterior cingulate cortex. In contrast, connectivity between the dorsal nexus, a region that plays a crucial role in the pathophysiology of depression, and two areas within the right dorsolateral prefrontal cortex was increased. These sleep deprivation–induced changes in resting-state connectivity indicate a shift in dominance from a more affective to a more cognitive network. This shift toward improved cognitive control should be particularly beneficial in depressed patients who suffer from rumination, negative anticipation, and excessive feelings of guilt and shame. Proc. Natl. Acad. Sci. U.S.A. 110 , 19597 (2013). [1]: pending:yes
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.