Abstract
Objective: The aim of this meta-analysis was to discover the effect of dominant and recessive genetic models of LSP1 gene rs3817198 polymorphism on breast cancer risk. Material and Method: We performed this meta-analysis according to PRISMA protocol. Three databases, including PubMed/Medline, Web of sciences, and EMBASE were searched. In this meta-analysis, we included all studies that evaluated the association between LSP1 gene rs3817198 and breast cancer risk. ORs and their reported 95% confidence interval (CI) for dominant and recessive inheritance models were extracted from final retrieved studies. ORs were pooled using both fixed and the random-effect models. Egger’s test and contour-enhanced funnel plot were used to evaluate publication bias and small study effect. Twelve publications were eligible for final analysis after observing our defined inclusion and exclusion criteria. Results: Totally, this meta-analysis composed of 15,530 cases and 20,258 controls. This study revealed a significant association between LSP1 gene rs3817198 polymorphism and breast cancer in the dominant genetic model (OR=1.07 [1.01-1.14]). Inversely, no association was found in the recessive genetic model (OR=1.10 [0.93-1.32]). Subgroup analysis displayed a significant association in population-based studies and European & American and African population only in the dominant genetic model. Begg’s funnel plot and Egger’s test revealed no publication bias. Conclusion: According to our findings, it seems that LSP1 gene rs3817198 polymorphism is associated with breast cancer risk and this risk is more prominent in Caucasians.
Highlights
Breast cancer is the most common cancer among women and it is the second cause of cancer-related death
Analysis The main analysis of this study revealed a significant association between Leukocyte-specific protein 1 (LSP1) gene rs3817198 polymorphism and breast cancer in the dominant genetic model (OR=1.07 [1.01-1.14], Figure 2)
Many attempts have been made to clarify the role of single nucleotide polymorphisms (SNPs) in breast cancer risk [4,5,6,7,8,9,10,11, 24] and it is still a topic of debate
Summary
Breast cancer is the most common cancer among women and it is the second cause of cancer-related death. Several studies showed no association between rs3817198 SNP and breast cancer [6,7,8], but there are pieces of evidence on the relationship between rs3817198 SNP and increased [9,10] or maybe decreased risk of breast cancer [11]. The aim of this metaanalysis was to predict the effect of dominant and recessive genetic models of LSP1 gene rs3817198 polymorphism on breast cancer risk
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