Abstract
Does the Benefit of Therapeutic Hypothermia in Refractory Status Epilepticus Depend on Seizure Etiology?
Highlights
Refractory status epilepticus (RSE) is seizure activity that persists despite acute administration of standard anticonvulsant therapy
Seizures persisted despite Therapeutic hypothermia (TH) in the three postcardiac arrest patients and all three expired
Our additional five cases suggest that RSE from etiologies other than anoxic brain injury post-cardiac arrest may have better outcomes with TH
Summary
Refractory status epilepticus (RSE) is seizure activity that persists despite acute administration of standard anticonvulsant therapy It often occurs after cardiac arrest, indicating a poor prognosis. It has been shown to terminate epileptiform discharges in both human and animal models [5,6,7] Given these results, there has been increasing interest in the use therapeutic hypothermia (TH) as an adjunct treatment for seizures not responsive to traditional abortive methods, i.e. refractory status epilepticus (RSE). As our experience and knowledge increases, TH may play an earlier and more integral role in protocols for treatment of status epilepticus At minimum, it is a promising adjunct therapy in some patients, but exactly who those patients are is yet to be determined
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