Abstract
A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and human herpes virus type 6 (HHV6) is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir.
Highlights
The human bocavirus (HBoV) was discovered in 2005 by the Swedish group of Tobias Allander and colleagues [1]
HBoV was classified as an autonomous parvovirus [3] rather than a Dependovirus like the Adenoassociated virus (AAV) there remains the possibility that HBoV infections depend on helper viruses or at least contributes synergistically to the clinical course
In the recent past human bocavirus has been frequently associated with severe diarrhoea and turned out to be a most frequent agent in this clinical disorder [13,14,15,16,17,18,19], leading to the assumption that HBoV is the causative agent despite the missing proof of Koch’s postulates for HBoV [2]
Summary
The human bocavirus (HBoV) was discovered in 2005 by the Swedish group of Tobias Allander and colleagues [1]. HBoV was detected in patients suffering from respiratory infections and gastrointestinal diseases, but a proof that HBoV is the causative agent in such cases is missing as it remains impossible so far to fulfil Koch’s modified postulates [2]. Based on the pathological and virological diagnoses antiviral therapy was started with Cidofovir During this therapy, the HHV6 viremia decreased but remained detectable in both serum and stool samples taken in two intervals of 14 days; thereby, most surprisingly, during the Cidofovir therapy HBoV became undetectable in the stool samples 2 weeks after the onset of the antiviral therapy while HHV6 remained positive
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
