Abstract
A retrospective (case-controlled) study was conducted with the aim of identifying the effect of the use of misoprostol on termination time in patients who did and did not undergo feticide procedures in second trimester pregnancy terminations. The sampling of the study consisted of 144 pregnant women who were diagnosed as having major fetal anomalies incompatible with life, and were recommended for termination of pregnancy. The investigation showed that feticide procedures were performed for 99 women, and feticide procedures were not performed for 45 women. Misoprostol protocol was administered for 48 hours in the termination period; whether the feticide procedure directly affected the termination duration in patients who did and did not undergo feticide was evaluated. Abortion/birth was achieved in 103 (71.5%) women during the first 48 hours. There was no significant difference between the termination duration of the misoprostol protocol among the women who did and did not undergo feticide. There was no significant difference between the termination durations and fetal biometric measurements (BPD, HC) except head diameters (p=0.020 and p=0.015). The misoprostol protocol is shown to be effective and safe for the termination of pregnancies during the second trimester. Feticide has no affect on the duration of termination.
Highlights
Fetal abnormality is known to be a major cause of peri-African Health Sciences to fetal or maternal reasons
There was no significant difference between the termination duration of the misoprostol protocol among the women who did and did not undergo feticide
We aimed to investigate the effect of the use of oral misoprostol after 200 mcg vaginal misoprostol (PGE1-Cytotec) administration on the termination duration in patients who did and did not undergo feticide in second trimester pregnancy terminations
Summary
Fetal abnormality is known to be a major cause of peri-. African Health Sciences to fetal or maternal reasons. Dilation and curettage is the most preferred method for the termination of pregnancies during the first trimester, but termination with this method during the second trimester is likely to cause problems. The width of fetal-placental units, increased uterine blood flow, and the unripe cervix complicate the procedure during the second trimester[5]. Termination during the second trimester is achieved with prostaglandins in today’s world. Misoprostol (15-deoxy-16-hydroxy16-methyl prostaglandin E1) is a synthetic Prostaglandin E1 (PGE1) analogue. PGE1 is used in the induction of labor because of its uterotonic effects and it provides cervical ripening[6]
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