Does bone marrow affect the radiological outcome when added to biphasic ceramic graft in treatment of benign bone lesions?

Abstract

The aim of this study is to describe the role of bone marrow aspirate in treatment of the benign bone lesions by comparing two groups of patients (16 patients in each group) with benign bone lesions treated with surgical curettage and filling the defect with either composite ceramic graft hydrated with bone marrow aspirate "group 1" or composite ceramic graft alone without a bone marrow aspirate "group 2". The mean age was 19.7years (group 1) and 18.5years (group 2). The mean size of the cavitary bone lesions was 29.2cm(2) (group 1) and 25.9cm(2) (group 2). The mean follow-up period was 47months. The percentage of ceraform resorption had increased from 31.3% at 6months to 75.4% at 36months for group 1 patients and from 20.9% at 6months to 60.3% at 36months for group 2 patients. The percentage of bone trabeculation through the cavitary defects had increased from 30.3% at 6months to 85.5% at 36months for group 1 patients and from 18.9% at 6months to 72.0% at 36months for group 2 patients. The mean of the percentage of ceraform persistence at 36months after its implantation was 24.6% for group 1 patients and 39.7% for group 2 patients. Adding bone marrow aspirate to ceraform biphasic ceramic had hastened the rate of its resorption and had decreased the rate of its persistence.