Abstract
Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are useful for diagnosis of the illness. Others are clinically important because of associations with a particular manifestation of SLE. Antibodies to RNA helicase A (anti-RHA) comprise a newly described class of SLE autoantibodies. These antibodies have so far been found only in SLE patients and differ substantially in prevalence and nature between Mexican and white American SLE patients. Study of anti-RHA may provide insights into the origin of population differences in SLE.
Highlights
Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups
SLE autoantibodies may inform us as to, and be involved in, pathogenesis of the illness. Such information might range from molecular mimicry [8] to toll-like receptor binding [9] to autoantibody immune complexes stimulating interferon, a key cytokine in the pathogenesis of SLE [10]
In a recent issue of Arthritis Research and Therapy, Monica Vázquez-Del Mercado and her colleagues extend their studies of a new autoantigen-autoantibody system, namely, antibodies binding RNA helicase A [1]
Summary
Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Systemic lupus erythematosus (SLE) is a complex disease, including serological differences between patients from different ethnicities [1]. Anti-dsDNA is associated with kidney disease [3]. SLE autoantibodies may inform us as to, and be involved in, pathogenesis of the illness.
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