Abstract

PURPOSE: Epithelial regeneration is sometimes promoted by hepatocyte growth factor (HGF). HGF has also been shown to be mitogenic for bronchial and alveolar epitheliums. Moreover, HGF protects alveolar epithelial cells from pulmonary fibrosis. It has been reported that monocyte chemoattractant protein-1 (MCP-1) plays an important role in the resolution and repair processes of acute pneumonia via enhancing the removal of neutrophils and HGF production by alveolar macrophages. We investigated the serum levels of these cytokines and the influence of monocyte/macrophage.

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