Abstract
Objective: The objective of this study was to evaluate mandibular osteoporotic alterations in patients with HIV infection in comparison to non-HIV-infected patients using panoramic radiographs. Material and Methods: 26 HIV-infected patients and 142 non-HIV-infected patients (control group) were included in this study. Panoramic radiographs of the participants were assessed considering mandibular cortical index (MCI). Non-parametric comparisons between groups were performed, using Mann-Whitney test, at a level significance level of p= 0.05. Results: HIV-infected patients presented lower bone mineral density (BMD) at mandible, assessed by MCI in panoramic radiographs when compared to non-HIV-infected patients. The medication intake of HIV-infected patients was highly heterogeneous and could not be associated to the low BMD presented in the mandibular cortex. Conclusions: HIV-infected patients may present lower mandibular BMD than non-HIV-infected patients. Keywords Panoramic radiograph; osteoporosis; bone mineral density; HIV.
Highlights
A pproximately 43 million people are infected by the human immunodeficiency virus (HIV), and the number of cases is increasing every year [1]
A detail of the HIV-infected patients with mandibular cortical index (MCI) C2 and C3, which is associated with low bone mineral density (BMD) at mandible according to medication intake is described
We found that HIVinfected patients presented lower mandibular BMD, when assessed using MCI in panoramic radiographs, when compared to non-HIVinfected patients
Summary
A pproximately 43 million people are infected by the human immunodeficiency virus (HIV), and the number of cases is increasing every year [1]. Osteoporosis is a worldwide prevailing disease affecting nearby 27.5 million only in Europe, and more than 20 million Brazilians over 65 years old [3,4,5]. This disorder occurs when the process of bone remodeling becomes unbalanced due to major reabsorption of osteoclasts rather than osteoblasts [6,7]. HIV patients can experience relatively higher reduction on bone mineral density (BMD) than general population [1]. Dual X-Ray Absorptiometry (DXA) is the method of choice to diagnose osteoporosis [9]
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