Abstract
A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2′,3′-c]phenazine (pidbp) and its ruthenium complexes [Ru(L) 2(pidbp)] 2+ (L = bpy (2, 2′- bipyridine), phen (1, 10 – phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, 1H NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex [Ru(bpy) 2(pidbp)] 2+ 4 exhibits its DNA “molecular light switch” properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen.
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