Abstract
Deoxyribonucleoside triphosphate (dNTP) concentrations were measured in bone marrow and peripheral blood leucocytes from seven patients with acute Thy-lymphoblastic leukaemia (Thy-ALL), 12 patients with acute myeloblastic leukaemia and 15 patients with acute non-T, non-B lymphoblastic leukaemia (c-ALL), and in thymocytes from patients with myasthenia gravis. Labelled thymidine and deoxycytidine incorporation into DNA was also studied. In Thy-ALL, dNTP concentrations were markedly increased compared with those in the other acute leukaemias. The dNTP concentrations in thymocytes were, however, similar to those in Thy-ALL. 3H-nucleoside incorporation studies showed a marked difference in labelled deoxycytidine incorporation and particularly in the deoxycytidine/thymidine DNA labelling ratio between Thy-ALL and the other cell types. We conclude that the pathways of DNA synthesis in Thy-ALL blasts are different from those in the cells from acute acute leukaemias and some but not all these differences may correspond to differences between normal cortical thymocytes and bone marrow cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
