Abstract
BackgroundJorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.MethodsDNA damage was assessed in the peripheral blood by the comet assay (tail intensity).ResultsThe results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.ConclusionThese results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
Highlights
Jorge Lobo’s disease, known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution
The animals were distributed into four groups: (G1) ten mice inoculated with the fungus and under dietary restriction, (G2) ten mice not inoculated with the fungus and under dietary restriction, (G3) ten mice inoculated with the fungus and on normal diet and (G4) ten mice not inoculated with the fungus and on normal diet
The results revealed that the infection by L. loboi did not have any influence on the body weight of the mice
Summary
Jorge Lobo’s disease, known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. The disease, known as lobomycosis or lacaziosis, is a chronic, granulomatous, cutaneous-subcutaneous, fungal infection caused by the fungus Lacazia loboi and characterized by isolated or multiple coalescing lesions. These lesions usually show a keloidal aspect and are located primarily on the auricular pavilion and limbs of patients [3,4]. Since it is not compulsory that cases of Jorge Lobo’s disease be reported, the actual number of patients is unknown; this affliction is endemic in the Brazilian Amazon region and has presented fewer cases in other countries [2,5].
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