DNA-based Isolation and the Structure Elucidation of the Budmunchiamines, Novel Macrocyclic Alkaloids from Albizia amara

Abstract

On the basis of DNA affinity, a novel isolate was obtained from an extract prepared from the seeds of Albizia amara. As determined by a series of spectroscopic techniques, the isolate was structurally defined as a mixture of three macrocyclic alkaloids of the pithecolobine type that differed only in the length of the aliphatic side chain. The 1 H- and 13 C-nmr spectral parameters were unambiguously assigned to these alkaloids, which were given the trivial names budmunchiamine A, B or C. With the exception of former studies performed with Pithecolobium saman, this is the only other report of pithecolobine alkoids being found in nature