Abstract
The adoptive cell transfer (ACT) of autologous tumor infiltrating lymphocytes (TIL) can mediate durable, complete tumor regression in approximately 20% of patients with metastatic melanoma. Recent observations suggest that autologous melanoma TIL administered to multiple patients in ACT protocols can recognize 1 or more tumor-specific somatic mutations, findings facilitated by recent advances in whole exome sequencing and RNA-seq methods.
Highlights
The adoptive cell transfer (ACT) of autologous tumor infiltrating lymphocytes (TIL) can mediate durable, complete tumor regression in approximately 20% of patients with metastatic melanoma
Recent observations suggest that autologous melanoma TIL administered to multiple patients in ACT protocols can recognize 1 or more tumor-specific somatic mutations, findings facilitated by recent advances in whole exome sequencing and RNA-seq methods
The TIL generated from 2 of the 5 patients who did not respond to ACT failed to recognize any mutated antigens tested, but recognized an autologous tumor cell line
Summary
Jessica S Crystal1*, Todd D Prickett, Jared J Gartner, Maria R Parkhurst, Yong-Chen Lu4, Alena Gros, Yong Li3, Kasia Trebska-Mcgowan, Mona El-Gamil, Steven A Rosenberg, Paul F Robbins. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015
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