Abstract
Background: Rapidly establishing the cause of neonatal jaundice is very important. Delaying an exact diagnosis can have lifelong consequences. Timely treatment, if possible, is a universal solution. Objectives: This study aimed to report on the prevalence & diagnostic approach of the myriad disorders causing persistent neonatal jaundice in patients presenting to the pediatric surgery unit of Saidu Group of Teaching Hospital (SGTH), Swat. Materials and Methods: Clinical chemistry and cause of disease were retrospectively analyzed in 40 infants (male n=21, 52.5%) that had presented with neonatal jaundice to SGTH, from January 2020 to December 2021. Results: The most common cause of persistent neonatal jaundice was biliary atresia (52 %) followed by idiopathic causes (15%) and Progressive familial intrahepatic cholestasis (10%). Conclusion: Although in the last 2 decades, new causes such as the progressive familial intrahepatic cholestasis followed by idiopathic cases have been identified biliary atresia still represents the major cause of persistent neonatal jaundice.
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