Abstract
OBJECTIVE: Our objective was to study the combined effect of taxol and tumor necrosis factor-a on the cytolysis of human ovarian carcinoma cell lines, because taxol has been shown to be active against ovarian carcinoma and has also been shown to increase tumor necrosis factor-α release from macrophages.STUDY DESIGN: The combined effect of taxol and tumor necrosis factor-α on the cell lines Caov-3, SK-OV-3, NIH: OVCAR-3, and A2780, which are sensitive to the cytolytic effect of tumor necrosis factor-α in the presence of inhibitors of protein synthesis, was investigated with a 24-hour chromium 51 release assay.RESULTS: At therapeutic concentrations taxol caused a significant increase in tumor necrosis factor-α-mediated cytolysis of Caov-3 and A2780 (p ≤ 0.05). By contrast, taxol caused a decrease in the tumor necrosis factor-α-mediated cytolysis of SK-OV-3 and NIH:OVCAR-3 (p ≤ 0.01).CONCLUSION: These results suggest that ovarian carcinomas have a heterogeneous response to the chemotherapeutic effect of taxol. (AM J OBSTET GYNECOL 1992;167:1870-6.)
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