Abstract
SUMMARYMarked diurnal variation in serum immunoreactive erythropoietin was seen in a healthy man both during a 4‐day control period and following acute loss of 450 g of blood by venesection. The highest concentrations of erythropoietin occurred around midnight and the lowest around noon. These findings emphasize the need to take account of diurnal changes in serum erythropoietin when assays for this hormone are used or assessed for their potential as diagnostic tools.
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