Abstract
Splenectomy was performed on CBA mice and the diurnal rhythm of mitotic activity in the corneal epithelium studied 5 days later, after preliminary injection of colcemid into the animals 3 h before sacrifice. In that part of the 24-h period that is characterized by a high mitotic index (from 3 a.m. to 3 p.m.) the index of c-mitoses in the experimental mice was significantly lower than in the control and the peak of mitotic activity was postponed. The duration of the phase of an increase in the number of cell divisions was shortened. The total number of c-mitoses in the control animals in the course of the 24-h period was 72.3% of the control number. The rate of physiological regeneration of the corneal epithelium was reduced in the splenectomized mice. It is suggested that the lymphoid system affects the entry of cells into mitosis in epithelial tissue and the formation of the wave of mitosis during the period of increased mitotic activity.
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