Abstract
Pupillary light reflex is mediated by intrinsic photosensitive retinal ganglion cells (ipRGCs) and the midbrain in human brain. The cells ipRGCs are highly sensitive to blue light (~ 480 nm). In this study, we evaluated diurnal changes in chromatic sensitivity of ipRGCs by measuring pupillary light reflex. The data showed that sensitivity to red and green light increased from morning to evening, but that to blue decreased from noon to evening. These results indicate that sensitivity of ipRGCs may decreases in evening.
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