Abstract
Disulfiram or diethyldithiocarbamate (DDC) significantly prolonged ethanol-induced loss of righting reflex in mice. The disappearance of ethanol from blood, and brain was significantly delayed in disulfiram-treated animals, suggesting an impairment in the activity of alcohol dehydrogenase in these animals. DDC, an active metabolite of disulfiram, inhibited mouse liver alcohol dehydrogenase (LADH) in vitro. Pyrazole, a known inhibitor of alcohol dehydrogenase, affected ethanol elimination and ethanol-induced loss of righting reflex in mice in a manner similar to that seen with disulfiram.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
