Abstract
CLEAR (Cross-Linked Ethoxylate Acrylate Resin) was introduced by Kempe and Barany in 1996 [1] and further developed in 1997 [2]. CLEAR possesses a highly branched, highly cross-linked ethylene glycol matrix which has excellent swelling properties in a variety of solvents including water. It has outstanding potential for peptide synthesis, especially for difficult sequences; yet its hydrophilic nature is also attractive for biological applications [3]. In order to probe the versatility of CLEAR, several classic organic transformations have been previously examined [4]. These include Mitsunobu and Suzuki couplings. In most cases, CLEAR resins provided organic products with purity and yields comparable to polystyrene supports. In this report we explore the use of CLEAR supports for on-resin disulfide-forming oxidations.
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