Abstract
The synthesis of phosphorothioate analogues of oligonucleotides by the oxidation of deoxyadenosine 3',5'-bisphosphorothioate (3) was attempted. Cyclization of 3 is much more efficient than oligomerization under all the conditions investigated. However, a preformed oligonucleotide carrying a 5'-terminal phosphorothioate group undergoes efficient chain-extension when oxidized in the presence of 3.
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