Abstract
ABSTRACT Cortisol production and metabolite excretion have been studied in 2 male infant siblings who manifested failure to thrive, salt wasting, elevated urinary Porter-Silber reacting steroids, and evidence of an 18-dehydrogenase defect in aldosterone biosynthesis (Pediatrics 41: 403, 1968). The present investigation demonstrates that under certain conditions cortisol production or regulation is also aberrant: (a) dexamethasone only suppressed cortisol production rate (CPR) and urinary tetrahydrocortisol (THF) and tetrahydrocortisone (THE) excretion partially in the hyponatremic state, and (b) CPR and urinary THF and THE excretion were reduced to markedly subnormal levels following initial restoration of salt balance with desoxycorticosterone acetate (DOCA) and NaCl. After prolonged DOCA and salt therapy, CPR and urinary cortisol metabolite excretion returned to normal and the partial resistance of CPR to dexamethasone suppression could no longer be demonstrated. These data suggest a relationship betwee...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
