Abstract
The distribution of vasoactive intestinal polypeptide (VIP) in the individual nuclei of the rat brain stem was examined. Highest VIP concentrations in brain stem (> 1 ng/mg protein) are confined to dorsal regions, including periaqueductal gray and structures under the fourth ventricle. VIP concentrations are moderately high (0.8–1 ng/mg protein) in gracile nucleus, area postrema, nucleus of the solitary tract, motor nucleus of the XIIth, locus ceruleus and dorsal tegmental nucleus. Cerebellum and pontine nuclei contained only very low levels (< 0.2 ng/mg protein) of VIP.
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