Abstract
In order to clarify the factors which enhance the efficacy of drug in cream, the correlation between the release of isothipendyl (IP) and the distribution of IP in the oil and aqueous phases of cream was investigated for creams with varied pHs. The distribution of IP in the phases of creams was measured by using ultracentrifugation and ultrafiltration methods. The release test of IP from cream was performed by using cellulose or dimethyl polysiloxane membrane. The release of IP through cellulose membrane was dependent on the amount of total IP in the aqueous phase of cream. On the other hand, the release of IP through dimethyl polysiloxane membrane showed the present of optimum pH value of cream, and the release was dependent on the product of amounts of the total IP and of free form IP in the aqueous phase. The results showed that it is necessary to use dimethyl polysiloxane membrane for the evaluation of the release of ionic drug from creams, and in order to obtain maximum release of drug, the pH of cream must be adjusted to the optimum pH value.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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