Abstract
Distribution of intramuscularly administered 14C-diethylstilbestrol(DES)in the chicken and laying hen was studied by whole body autoradiography and impulse counting techniques. In both groups the liver showed the highest concentration of 14C. The 14C-level of the chicken liver and bile appeared greater than the same level in the hen. The 14C-content of the hen kidney was twice that found in the chicken. These findings could mean that the metabolic and excretory function of the kidney is less developed in the young chicken than in the adult bird and that the chicken liver may compensate for insufficient kidney function. The lower l4G-concentration of the chicken adrenal as compared to the hen, could indicate a reduced physiological activity of the young adrenal. The accumulation of radioactivity in the membrane of the follicular yolk should represent excretion. Low 14C-content was found in the skeletal muscle. It is concluded that consumer products based mainly on the liver from DES-treated chickens should not be used for consumption.
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